Amy Prentiss is an American police drama television series which aired on NBC. It is a spinoff of Ironside, and aired as part of the NBC Mystery Movie from 1974-1975.

Jessica Walter stars as Amy Prentiss, a relatively young investigator who becomes the first female Chief of Detectives for the San Francisco Police Department. Helen Hunt, in an early role, played Prentiss' pre-teen daughter, Jill. Four 2-hour episodes were aired.

Guest stars in the series' brief run included William Shatner, Cameron Mitchell, Don Murray, Joyce Van Patten and Jamie Farr.