The Panther Claw organization is driven by a relentless pursuit of wealth, using any means necessary to achieve their goals. However, their plans start to unravel thanks to the unexpected interference of a seemingly ordinary girl. This girl, who initially encounters Panther Claw by chance, turns out to be Kisaragi Honey, the ‘daughter’ of the brilliant cyberneticist Dr. Kisaragi Koshirou. Recognizing her value, Panther Claw’s four members race to capture Cutie Honey.

Kisaragi Honey, also known as Cutie Honey, is not alone in her fight. She is joined by two allies, Saotome Miki (Sister Miki) and Kenmochi Yuki (Sister Yuki). Together, they work to thwart Panther Claw’s schemes and protect Honey from being exploited.