Programa do Jô is a Brazilian late-night talk show broadcast by Rede Globo since April 3, 2000. It is shown after the late-night news bulletin, Jornal da Globo.

The program is hosted by Brazilian comedian, author and musician Jô Soares, and follows the format of American talk shows such as Late Show with David Letterman. It began its life as Jô Soares Onze e Meia in 1988 on SBT. Following Jô Soares' return to Globo in 2000, the show was renamed as Programa do Jô, retaining the same format and late-night time slot.

The show usually features interviews with 3 guests and a live musical performance. Usually, if one of the guests is a musician or band, they return to perform at the end of the show. There are also occasions when the first guest stays on to continue the interview past the first commercial break, in which case the show only features 2 interviews. In most cases, the interviews are longer and more in-depth than those on Letterman's show.